Effect of single doses of entacapone and tolcapone on AUC and elimination half-life of l-dopa in patients with PD
| Parameter | Entacapone (200 mg) | Tolcapone (200 mg) | Reference |
|---|---|---|---|
| AUC | +23% | +32% | Ruottinen and Rinne, 1996a |
| Tohgi et al., 1995 | |||
| +29% | +51% | Ruottinen and Rinne, 1996b | |
| Davis et al., 1995a | |||
| +38% | +53%6-a | Kaakkola et al., 1994b | |
| Roberts et al., 1993b | |||
| +46% | +58% | Myllylä et al., 1993 | |
| Limousin et al., 1995 | |||
| +48% | Nutt et al., 1994 | ||
| T 1/2el | +17%6-a | +32%6-a | Ruottinen and Rinne, 1996b |
| Roberts et al., 1993b | |||
| +32% | +77% | Myllylä et al., 1993 | |
| Tohgi et al., 1995 | |||
| +39% | +79% | Ruottinen and Rinne, 1996a | |
| Limousin et al., 1995 | |||
| +75% | Nutt et al., 1994 |
↵6-a 400 mg.