COMT Inhibitor | Dose/Day | Treatment Duration | Decrease in 3-OMD AUC | Reference |
---|---|---|---|---|
mg | % | |||
Entacapone | 600–800 | 1 wk | 44 | Kaakkola et al., 1994b |
800–1200 | 4 wk | 45 | Ruottinen and Rinne, 1996b | |
800–2000 | 4 wk | 63 | Ruottinen and Rinne, 1996c | |
1200 | 2 mo | 59 | Nutt et al., 1994 | |
800–2000 | 6 mo | 58 | Parkinson Study Group, 1997 | |
Tolcapone | 300 | 6 wk | 66 | Davis et al., 1997 |
600 | 6 wk | 79 | Davis et al., 1997 | |
600 | 7–8 wk | 79 | Yamamoto et al., 1997 |