Main characteristics of polypeptide growth factors and their receptors
| Ligand | Length | MW | Human Chromosomal Location | Receptor | Length | MW | Human Chromosomal Location |
|---|---|---|---|---|---|---|---|
| aa | kDa | aa | kDa | ||||
| EGF | 53 | 6 | 4 | EGF-R | 1186 | 170 | 7 |
| aFGF | 115 | 16 | 5 | FGF-R-1 | 801 | 160 | 8 |
| bFGF | 155 | 16–18 | 4 | FGF-R-2 | 800 | 135 | 10 |
| FGF-R-3 | 784 | 135 | 4 | ||||
| FGF-R-4 | 778 | 140 | 5 | ||||
| IGF-I | 70 | 7.6 | 12 | IGF-I-R | 706 (α) | 130 (α) | 15 |
| 196 (β) | 90 (β) | ||||||
| IGF-II | 60 | 7.4 | 11 | IGF-II-R | 260 | 6 | |
| TGF-α | 50 | 6 | 2 | EGF-R | 1186 | 170 | 7 |
| TGF-β1 | 112 | 25 | 19 | TGF-R-β1 | 479 | 50–60 | unknown |
| TGF-β2 | 112 | 25 | 1 | TGF-R-β2 | 542 | 65 | unknown |
| TGF-β3 | 112 | 25 | 4 | ||||
| VEGF-1 | 121 | 6 | Flt-1 | 1273 | 180 | 13 | |
| VEGF-2 | 165 | 6 | Flk-1/KDR | 1367 | 230 | 5 | |
| VEGF-3 | 189 | 451-a | 6 | ||||
| VEGF-4 | 205 | 6 | Flt-4 | 1298 | 170 | 5 | |
| HGF/SF | 728 | 62 (α) | 7 | Met | 1380 | 50 (α) | 7 |
| 34 (β) | 145 (β) | ||||||
| PDGF | 110–125 (A) | 14–18 | 7 | PDGF-R | 1066 (α) | 170 | 4 |
| 109 (B) | 16 | 22 | 1074 (β) | 180 | 5 |
aa, amino acids.
↵1-a Molecular weight of native VEGF.