Table 1

Differential molecular phenotypes among various rat cardiac disease models

SHRSHRSPAortic BandingCoronary Artery LigationAortocaval ShuntOLETF
DiseaseModerate hypertensionSevere hypertensionAcute pressure overloadMyocardial infarctionVolume overloadDiabetes
LV mRNA
 β-MHC
 α-MHC
 Skeletal α-actin
 ANF
 TGF-β1
 Collagen I
 Collagen III
Reference Ohta et al., 1996a Kim et al., 1996b Parker et al., 1991;  Villarreall et al., 1992 Yoshiyama et al., 1999 Kim et al., 1997b Yagi et al., 1997
  • LV, left ventricular; ↑, up-regulation; →, no change; ↓, down-regulation.