Table 3

In vivo molecular effects of AT1 receptor antagonists on various rat vascular disease models

Rat ModelAT1 Receptor AntagonistDosageSuppressionReference
mg/kg/day
SHRSC-5245850TGF-β1, collagen type IV, and fibronectin mRNAs Ohta et al., 1994
SHRSPCandesartan0.1, 1, and 10TGF-β1, collagen types I, III, and IV, fibronectin, and laminin mRNAs Kim et al., 1995b
Balloon injuryCandesartan10c-fos, c-jun, Egr-1, ODC, and fibronectin mRNAs Kim et al., 1995a
Balloon injuryE417720JNK activity, ERK activity, and AP-1 activity Kim et al., 1998
Balloon injuryCandesartan10PDGF-α and -β receptor tyrosine phosphorylation Abe et al., 1997
OLETF ratsE417710TGF-β1 Kim et al., 1997c