Table 5

Comparison of in vivo pharmacological actions between AT1receptor antagonist and ACE inhibitor

AT1 Receptor AntagonistACE Inhibitor
AT1 receptorDirect inhibitionIndirect inhibition
ACE activityNo effectDirect inhibition
Plasma renin↑↑
Plasma Ang II↑↓
AT2receptorStimulationInhibition
Bradykinin→↑
Dry coughNoYes

  • ↑, increase; →, no change; ↓, decrease.