Nomenclature | Accession Number | Pharmacology | Biology | |||||
---|---|---|---|---|---|---|---|---|
Name | Previous Names | Gene Chromosome | Human | Mouse | Selective Chemokines | Selective Nonpeptide Small Molecule Antagonists (Kd) | Major Phenotypes of Genetically Deficient Mice/Humans | HIV Coreceptor Activity? |
CXC chemokine receptors | ||||||||
CXCR1 | IL8RA, IL-8R-I, IL-8Rα | IL8RA 2q34-q35 | P25024 | N.D. | None | None | N.A. | N.D. |
CXCR2 | IL8RB, IL-8R-II, IL-8Rβ | IL8RB 2q34-q35 | P25025 | P35343 | GROα, NAP-2, ENA-78 | SKB RS-145004-000 (35 nM) | Mice:Defective neutrophil trafficking and distribution and B cell distribution; resistance to atherogenesis | N.D. |
CXCR3 | IP10/Mig R, GPR9 | GPR9 Xq13 | P49682 | AF045146 | IP-10, I-TAC, Mig | None | N.A. | N.D. |
CXCR4 | HUMSTSR, LESTR, fusin, HM89, LCR1, NPYR, D2S201E | CXCR4 2pter-qter | P30991 | P70658 | SDF-1 | AMD3100 | Mice:Defective development of heart, cerebellum, stomach vasculature, B cell lymphopoiesis and bone marrow myelopoiesisEmbryonic lethal | X4 strains |
CXCR5 | BLR-1, MDR15 | BLR1 11 | P32302 | Q04683 | BCA-1 | None | Mice:Defective B cell trafficking and development of inguinal nodes, Peyer's patches and germinal centers | HIV-2 |
CC chemokine receptors | ||||||||
CCR1 | CKR1, CC CKR1, MIP-1α/RANTES, CMKBR1 | CCR1 3p21 | P32246 | P51675 | HCC-1 | Berlex RS-162993-000 (6 nM) | Mice: Susceptibility to A. fumigatus; resistance to pancreatitis-induced alveolitis; defective neutrophil chemotaxis, Th1/Th2 balance, hematopoiesis, and granuloma formation: susceptibility to nephrotoxic nephritis; resistance to acute and chronic cardiac allograft rejection | N.D. |
CCR2 | CKR2, CC CK2, CC CKR2, MCP-1, CMKBR2 | CCR2 3p21 | P41597 | P51683 | MCP-1 | Roche RS-511336-000 (33 nM) | Mice: Susceptibility to Listeria;resistance to atherogenesis; defective monocyte trafficking, Th1/Th2 balance, and granuloma formation | Some dual-tropic strains |
CCR3 | CKR3, CC CKR3, eotaxin receptor, CMKBR3 | CCR3 3p21 | P51677 | P51678 | Eotaxin, eotaxin-2 | Banyu RS-163883-230 (40 nM) | N.A. | Some X4, R5, and dual-tropic strains |
CCR4 | CKR4, CC CKR4, K5-5, CMKBR4, CHEMR1 | CCR4 3p22 | P51679 | P51680 | TARC, MDC | None | N.A. | N.D. |
CCR5 | CKR5, CC CKR5, ChemR13, CMKBR5 | CCR5 3p21 | P51681 | P51682 | MIP-1β | Takeda TAK-779 (1 nM) | Mice: Susceptibility to Listeria, lps, and DTH reaction. Human: Resistance to HIV | All R5 and dual-tropic strains |
CCR6 | GPR-CY4, CKR-L3, STRL22, DRY-6, DCR2, BN-1, GPR29, CMKBR6 | CCR6 6q27 | P51684 | AJ222714 | LARC | None | N.A. | N.D. |
CCR7 | EBI-1, BLR-2, CMKBR7 | CCR7 17q12-q21.2 | P32248 | P47774 | ELC, SLC | None | N.A. | N.D. |
CCR8 | TER1, CKR-L1, GPR-CY6, ChemR1, CMKBR8 | CCR8 3p22-p23 | P51685 | AF001277 | I-309 | None | N.A. | Some X4, R5, and dual-tropic strains |
CCR9 | GPR 9-6 | Unnamed 3p21.3-22 | P51686 | AJ132336 | TECK | None | N.A. | N.D. |
CCR10 | GPR2 | GPR2 17q21.1-q21.3 | U13667 | ESkine | None | N.A. | ||
CCR11 | PPR1 | 3p22 | AF193507 | N.A. | TBA | |||
C chemokine receptor | ||||||||
XCR1 | GPR5 | GPR5 3p21 | P46094 | N.A. | Lymphotactin | None | N.A. | N.D. |
CX3C chemokine receptor | ||||||||
CX3CR1 | GPR13; V28; CMKBRL1 | CX3CR1 3pter-p21 | P49238 | AF102269 | Fractalkine | None | N.A. | Some X4, R5, and dual-tropic strains |
Chemokine-binding proteins | ||||||||
Duffy | DARC; glycoprotein D | Fy 1q21-q22 | Q16570 | AF016584 | None | Yes | Human:Resistance to P. vivax malaria | N.D. |
D6 | CCR9, CCR10 | CMKBR9 3p21 | Y12815 | Y12879 | None | N.A. | N.A. | N.D. |
N.D., not determined; N.A., not available. Two splice variants affecting the ORF have been identified for each of the following receptors: CXCR4, CXCR5, CCR2, and CCR9; however, biological or pharmacological significance has not been determined. Other HIV coreceptors include US28 (Pleskoff et al., 1997), the leukotriene B4 receptor (Owman et al., 1998), and the orphans Apj (Choe et al., 1998), BOB/GPR15 (Deng et al., 1997; Farzan et al., 1997), STRL33/Bonzo/TYMSTR (Deng et al., 1997; Liao et al., 1997; Loetscher et al., 1997), GPR1 (Farzan et al., 1997), ROC1 (Shimizu et al., 2000); and ChemR23 (Samson et al., 1998).