Table 2

References for the effect of stimulation of presynaptic receptor (ionotropic and metabotropic) activation by major transmitters and ATP (adenosine) on [Ca2+]o-dependent transmitter release in the CNS [neurochemical and electrophysiological (EP) evidence]

Increase of ReleaseInhibition of Release
Via AutoreceptorsVia HeteroreceptorsVia AutoreceptorsVia Heteroreceptors
Glutamatergic (Glu)AMPA,4 NMDA,46 KA49 nAChR (α7),17 P2X,34 A2A,36GABAA 53 mGluR4/7/8 (EP),6KA5 GABAB,15 M2 (EP),18A1,48 α2 52
GABAergic (GABA)D1,3 nAChR (α7 or α4β2, EP),1 5 HT3(EP)21 GABAB 10 mGluR2/3 (EP),19KA,16 M2,26 D2,32 5HT1A(EP),20 A2A (EP)51
Cholinergic (ACh)nAChR9 A2A,37P2X38 M2,8 M47 5-HT1B,22A1 (EP),35 D2,42 A1 43
Noradrenergic (NE)α1 11 NMDA23/AMPA/KA,24nAChR(α3β2),2 GABAA,25 P2X,405-HT3 57 α2A 12 GABAB,25P2Y,39 A1 50
Serotonergic (5-HT)5-HT3 55 AMPA27 5-HT1B/D,13,145-HT1D 54 α2A,30GABAA,28 GABAB,29 M131
Dopaminergic (DA)P2X,41 non-NMDA,44 nAChR (α4β2,45 α3β247), 5-HT3 56 D2 33
  • 1 (α7, EP) Alkondon et al., 1996, 1997. (α4β2, EP)Lu et al., 1998; Lena and Changeux, 1997.

  • 2 (α3β2) Vizi et al., 1995; Sershen et al., 1997.

  • 3 (D1) Floran et al., 1990.

  • 4 (AMPA) Barnes et al., 1994; Chaki et al., 1998.

  • 5 (KA) Chittajallu et al., 1996.

  • 6 [mGluR4/7/8 (EP)] Scanziani et al., 1997.

  • 7 (M4) McKinney et al., 1993.

  • 8 (M2) Richards, 1990.

  • 9 (nAChR) Wilkie et al., 1996.

  • 10 (GABAB) Pittaluga et al., 1987.

  • 11 (α1) Pastor et al., 1996.

  • 12 (α2A) Kiss et al., 1995; and see Table 3.

  • 13 (5-HT1B/D) Maura et al., 1986.

  • 14 (5-HT1B/D) Limberger et al., 1991; Jackisch et al., 1999a.

  • 15 (GABAB) Pende et al., 1993.

  • 16 (KA) Cunha et al., 1997.

  • 17 (α7) Gray et al., 1996.

  • 18 (M2) Marchi and Raiteri, 1989; (EP) Hasselmo and Bower, 1992.

  • 19 [mGluR2/3 (EP)] Poncer et al., 1995.

  • 20 [5-HT1A (EP)] Bijak and Misgeld, 1997.

  • 21 [5-HT3 (EP)] Peters et al., 1992; Piguet and Galvan, 1994.

  • 22 (5-HT1B) Maura and Raiteri, 1986.

  • 23 (NMDA) Pittaluga and Raiteri, 1990.

  • 24 (AMPA/KA) Pittaluga and Raiteri, 1992a; Desai et al., 1994,1995; Patel and Croucher, 1997; Cowen and Beart, 1998.

  • 25 (GABAB) Fung and Fillenz, 1983.

  • 26 (M2) Raiteri et al., 1990b; (EP) Levey et al., 1995.

  • 27 (AMPA) Pittaluga et al., 1997.

  • 28 (GABAA) Balfour, 1980.

  • 29 (GABAB) Andrews et al., 1992.

  • 30 (α2A) Gobbi et al., 1990; MacDonald et al., 1997.

  • 31 (M1) Marchi et al., 1986.

  • 32 (D2) Floran et al., 1997; Hársing and Zigmond, 1997.

  • 33 (D2) Hoffmann and Cubeddu, 1984.

  • 34 (P2X) Gu and MacDermott, 1997.

  • 35 (A1) Morton and Davies, 1997.

  • 36 (A2A) Popoli et al., 1995.

  • 37 (A2A) Cunha et al., 1994, 1995; Brown et al., 1990.

  • 38 (P2X) Sperlágh and Vizi, 1991; Sun and Stanley, 1996.

  • 39 (P2Y) von Kugelgen et al., 1994; Koch et al., 1997.

  • 40 (P2X) Boehm, 1999.

  • 41 (P2X) Zhang et al., 1996.

  • 42 (D2) Hoffmann and Cubeddu, 1984.

  • 43 (D2) Cunha et al., 1994; Jackisch et al., 1984.

  • 44 (non-NMDA) Petitet et al., 1995.

  • 45 (nAChR, α4β2) Grady et al., 1994.

  • 46 (NMDA) Montague et al., 1994 (via NO production).

  • 47 (nAChR, α3β2) Kulak et al., 1997.

  • 48 (A1) Corradetti et al., 1984; Fastbom and Fredholm, 1985.

  • 49 (KA) Terrian et al., 1991; Malva et al., 1996.

  • 50 (A1) Harms et al., 1978; von Kügelgen et al., 1992.

  • 51 (A2A) Kirk and Richardson, 1994; (EP) Mori et al., 1996.

  • 52 (α2) Kamisaki et al., 1992; Bickler and Hansen, 1996.

  • 53 (GABAA) Herrero et al., 1999.

  • 54 (5-HT1D) Galzin et al., 1992 (human); Maura et al., 1993 (human).

  • 55 (5-HT3) Martin et al., 1992; Bagdy et al., 1998.

  • 56 (5-HT3) Zazpe et al., 1994.

  • 57 (5-HT3) Allgaier et al., 1995.