Epitopes on tumor/angiogenic vascular endothelium which differentiate between normal and disease vasculature may be suitable for drug targeting or diagnostic purposes. Targets presented by molecules specific for tumor-associated basement membrane, extracellular matrix, or nonendothelial cell components have not been included.
| Target Epitope | Reference |
|---|---|
| 30.5-kDa. antigen | Hagemeier et al., 1986 |
| CD34 | Schlingemann et al., 1990 |
| VEGF/VEGF receptor complex | Ramakrishnan et al., 1996 |
| VEGF receptor | Dvorak et al., 1991 |
| Endosialin | Rettig et al., 1992 |
| E-selectin | Nguyen et al., 1993 |
| αvintegrins | Brooks et al., 1994a |
| Endoglin | Burrows et al., 1995 |
| Tie2 | Sato et al., 1995 |
| TNFα receptor | Eggermont et al., 1996 |
| CD44 | Griffioen et al., 1997 |
| Angiostatin receptor | Moser et al., 1999 |
| Endostatin receptor | not identified at present |
| CM101-binding protein | not identified at present |
| MMP-2/MMP-9 | Koivunen et al., 1999 |