Localization and relative abundance of type I and type II PACAP binding sites in rat peripheral tissues
| Structures | Type I | Type II | References |
|---|---|---|---|
| Eye | |||
| Choroid | + | + | Nilsson et al., 1994; D'Agata et al., 1998 |
| Retinal papilla | ++ | − | Nilsson et al., 1994; D'Agata et al., 1998 |
| Endocrine glands | |||
| Anterior pituitary | ++/+++ | ++ | Gottschall et al., 1990; Lam et al., 1990;Huang et al., 1993 |
| Adrenal gland | |||
| Glomerulosa tissue | + | Hinson et al., 1999 | |
| Medulla-Chromaffin cells | ++ | −/+ | Shivers et al., 1991; Watanabe et al., 1992 |
| Pancreas | ++ | Gourlet et al., 1991b; Robberecht et al., 1991b; Kashimura et al., 1993; Schmidt et al., 1993 | |
| Liver | + | ++ | Gottschall et al., 1990; Robberecht et al., 1991a; Shivers et al., 1991; Guijarro et al., 1992, 1995; Huang et al., 1993; Nguyen et al., 1993; Bitar et al., 1994; Gagnon et al., 1994 |
| Gonads | |||
| Testis | − | Lam et al., 1990 | |
| Spermatogonia and primary spermatocytes | ++ | Shivers et al., 1991 | |
| Seminiferous tubules | −/++ | Shivers et al., 1991 | |
| Late spermatids | + | Shivers et al., 1991 | |
| Leydig cells | + | ++ | Hueso et al., 1989; Romanelli et al., 1997 |
| Epithelial cells from epidymydal tubules | + | Shivers et al., 1991 | |
| Prostate | +/++ | Prieto and Carmena, 1983; Shivers et al., 1991; Juarranz et al., 1999a | |
| Seminal vesicles | + | Shivers et al., 1991 | |
| Ovary | ++ | Gottschall et al., 1990 | |
| Cardiovascular system | |||
| Arteries | + | ++ | Huang and Rorstad, 1987; Amenta et al., 1991; Huang et al., 1993 |
| Heart | − | Shivers et al., 1991 | |
| Urinary tract | |||
| Kidney | −/+ | ++ | Lam et al., 1990;Shivers et al., 1991; Magistretti et al., 1998b |
| Respiratory tract | |||
| Lung | +++ | Gottschall et al., 1990; Lam et al., 1990;Shivers et al., 1991; Bitar and Coy, 1993; Huang et al., 1993;Sakakibara et al., 1994; Sreedharan et al., 1995 | |
| Digestive system | |||
| Colon | + | ++ | Broyart et al., 1981; Prieto et al., 1981; Lam et al., 1990; Ekblad, 1999 |
| Duodenum | ++ | Gottschall et al., 1990 | |
| Lymphoid tissues | |||
| Lymphoid cells | ++ | Calvo et al., 1986 | |
| Macrophages | ++ | + | Sakakibara et al., 1994 |
| Spleen | ++ | Wiedermann et al., 1988; Tatsuno et al., 1991b | |
| Thymus | − | ++ | Gottschall et al., 1990; Shivers et al., 1991 |
The symbols provide a semi-quantitative evaluation of the density of PACAP binding sites. +++, high density; ++, moderate density; +, low density; −, no binding sites.