Table 7

Localization and relative abundance of PACAP receptor mRNAs in rat peripheral tissues

StructuresPAC1-RVPAC1-RVPAC2-RReferences
Peripheral nervous system
 Superior cervical ganglia++/+++ Nogi et al., 1997b; Braas and May, 1999
 Cardiac ganglia+ Braas et al., 1998
Eye
 Retina+++ D'Agata and Cavallaro, 1998
 Ganglion cells++ Seki et al., 1997
Endocrine glands
 Anterior pituitary++/+++−/++/++ Lutz et al., 1993; Usdin et al., 1994; Rawlings et al., 1995; Vertongen et al., 1995b; Hashimoto et al., 1996a; Shioda et al., 1997a
  GH cells+ Vertongen et al., 1995b
  PRL cells+++ Vertongen et al., 1995b
 Intermediate lobe of the pituitary−/++ Usdin et al., 1994; Hashimoto et al., 1996a; Shioda et al., 1997a
 Posterior pituitary−/+ Hashimoto et al., 1996a; René et al., 1996; Shioda et al., 1997a
 Adrenal gland++ Hashimoto et al., 1993
  Cortex+++ Usdin et al., 1994; Nogi et al., 1997a
  Medulla-Chromaffin cells+++++ Usdin et al., 1994; Moller and Sundler, 1996; Nogi et al., 1997a
 Pancreas++++ Filipsson et al., 1998b; Tamakawa et al., 1998
  Pancreatic beta islets++++ Usdin et al., 1994; Chatterjee et al., 1996; Filipson et al., 1998a
 Liver+++ Hosoya et al., 1993; Usdin et al., 1994
Gonads
 Testis+++ Usdin et al., 1994
  Early germ cells++ Usdin et al., 1994;Krempels et al., 1995
  Seminiferous tubules+ Krempels et al., 1995
 Ovary
  Granulosa and cumulus cells++/++ Usdin et al., 1994; Scaldaferri et al., 1996; Shioda et al., 1996; Kotani et al., 1998; Park et al., 2000
  Corpus luteum+ Kotani et al., 1997
Urinary tract
 Kidney++ Usdin et al., 1994
Respiratory tract
 Lung++++ Ishihara et al., 1992; Hosoya et al., 1993; Usdin et al., 1994; Chatterjee et al., 1996; Pei, 1998
 Tracheo-bronchial wall++ Ishihara et al., 1992; Sreedharan et al., 1993; Usdin et al., 1994
Digestive system
 Intestine++ Ishihara et al., 1992; Usdin et al., 1994
 Stomach+ Usdin et al., 1994; Teng et al., 1998
  Gastric enterochromaffin-like cells+ Zeng et al., 1999
Lymphoid tissues
 Spleen+/++ Usdin et al., 1994
 Thymus+++ Usdin et al., 1994
  Macrophages+ Pozo et al., 1997
  Lymphocytes++ Waschek et al., 1995a; Delgado et al., 1996c,d; Ganea 1996; Johnson et al., 1996
  • The symbols provide a semi-quantitative evaluation of the density of PACAP receptor mRNAs. +++, high density; ++, moderate density; +, low density; −, no hybridization signal.