Effects of PACAP on pituitary cells
| Cell Type | Second Messenger Coupling | Hormone Release and/or mRNA Expression | References |
|---|---|---|---|
| Gonadotrope cells | ↑ cAMP, ↑ IP turnover ↑ [Ca2+]i | ↑/→ LH release, ↑/→ FSH release | Miyata et al., 1989; Culler and Paschall, 1991;Canny et al., 1992; Gracia-Navarro et al., 1992; Leonhardt et al., 1992; Perrin et al., 1993; Rawlings et al., 1993; Hashizume et al., 1994 |
| ↑ LH mRNA, → FSH mRNA | |||
| Somatotrope cells | ↑ cAMP, ↑ [Ca2+]i | ↑/→ GH release | Miyata et al., 1989; Canny et al., 1992; Goth et al., 1992; Gracia-Navarro et al., 1992; Hart et al., 1992; Jarry et al., 1992; Leonhardt et al., 1992; Nagy et al., 1993; Rawlings et al., 1993; Wei et al., 1993; Yada et al., 1993; Hashizume et al., 1994; Velkeniers et al., 1994; Rousseau et al., 1999 |
| Lactotrope cells | ↑ [Ca2+]i | ↑/↓/→ PRL release, ↑/→ PRL mRNA expression | Miyata et al., 1989; Gracia-Navarro et al., 1992; Hart et al., 1992; Jarry et al., 1992; Leonhardt et al., 1992; Nagy et al., 1993; Arbogast and Voogt, 1994; Hashizume et al., 1994; Velkeniers et al., 1994; Yamauchi et al., 1995 |
| Corticotrope cells | ↑ [Ca2+]i | ↑/→ ACTH release | Miyata et al., 1989; Culler and Paschall, 1991; Canny et al., 1992; Gracia-Navarro et al., 1992; Koch et al., 1993 |
| Thyrotrope cells | ↑ [Ca2+]i | → TSH release | Miyata et al., 1989;Canny et al., 1992; Gracia-Navarro et al., 1992; Hart et al., 1992 |
| FS cells | ↑ cAMP, ↑ [Ca2+]i | ↑ IL-6 release | Miyata et al., 1989; Tatsuno et al., 1991c; Yada et al., 1993 |
| Fibroblasts | ↑ cAMP | Koch and Lutz-Bucher, 1992b | |
| Melanotrope cells | ↑ cAMP | ↑ α-MSH release | Koch and Lutz-Bucher, 1992b |
↑, stimulatory effect; ↓, inhibitory effect; →, no effect.