Channel Family | Therapeutic Indication(s) | Compounds |
---|---|---|
Kv1.3 | Immunosuppressant | CP308408, UK 78,282 |
Kv1.5 | Atrial fibrillation | |
Kv (other) | Multiple sclerosis (axonal regeneration) | Fampridine (4-aminopyridine) |
Epilepsy, ischemia | BIIA 0388 | |
hERG/IKr | Atrial fibrillation/flutter | Dofetilide (Tikosyn) |
Arrhythmia | Ibutilide (Corvert injection) (also increases Na+ current) | |
Almokalant | ||
E4031 | ||
MK 499 | ||
Sematilide | ||
D-Sotalol | ||
KvLQT1-minK/IKS | Arrhythmia | Chromanol 293B HMR1556 |
E-047/1 | ||
L768673 | ||
IKr and IKs | Arrhythmia, angina | Ambasilide (LU 47710) |
Azimilide (NE 10064) (also L-type CaCh blocker) | ||
Tedisamil (also Na+ channel blocker) | ||
ITO | Arrhythmia | Clofilium |
KCNQ3/KCNQ4 | Alzheimer's disease | DMP543 |
KATP | Ventricular arrhythmia, heart failure, cardiac arrest | HMR 1098, HMR 1883 |
Type II diabetes | Tolbutamide | |
Chlorpropamide | ||
Glibenclamide | ||
Glipizide | ||
Nategliniide | ||
Repagliniide |