Selected mediators of PMN migration and their effects
| Summary of Effects | |
|---|---|
| Cytokines | |
| TNF | Induces P-selectin, ICAM-1 and IL-8 in ECs, shedding of L-selectin, expression of CD18 on PMNs, inhibition of PMN chemotaxis |
| IL-1 | Induces P-selectin, ICAM-1 in ECs, shedding of L-selectin, expression of CD18 on PMNs |
| IFN-γ | Induces P-selectin, ICAM-1 in ECs, shedding of L-selectin, expression of CD18 on PMNs |
| Chemoattractants | |
| PAF | PMN chemotaxin, induces EC and PMN expression of adhesion molecules |
| LTB4 | PMN chemotaxin, induces EC and PMN expression of adhesion molecules |
| FMLP | PMN chemotaxin, induces EC and PMN expression of adhesion molecules, desensitizes CXC receptors |
| C5a | PMN chemotaxin, induces PMN adhesion molecules, desensitizes PMNs to other chemoattractants |
| Chemokines1-a (CXC) | |
| IL-8 | Chemotactic for human, rabbit, and bovine PMNs; induces shedding of L-selectin and expression of CD18 on PMNs; systemic administration inhibits PMN migration in vivo |
| MIP-2 (CINC-3) | Chemotactic for rat PMNs, induces shedding of L-selectin and expression of CD18 on PMNs |
IFN-γ, interferon-γ.
↵1-a See Rollins (1997) for a detailed review on chemokines.