Therapeutic intervention and targets
| Inflammatory Target | Proposed Therapies |
|---|---|
| Cytokine production, activity | Receptor antagonists, antibodies, steroids, NSAIDs?, lipocortin nonapeptides, LPS analogs |
| Chemokine production, activity | Receptor antagonists, antibodies, steroids, NSAIDs? |
| Rolling, tethering of PMNs | Fucoidan, glycomimetics |
| Firm adhesion | Leumedins, ligand-based peptide inhibitors, NSAIDs, HMG-CoA reductase inhibitors, nitric oxide donors, LPS analogs? |
| Diapedesis | Antiproteases?, ligand-based peptides? |