Pathway defects, known biochemical functions, and homologs of relevant rad and rad-related yeast mutants: checkpoint mutants
| Mutants | Functions | Human Homologs | |
|---|---|---|---|
| S. pombe | S. cerevisiae | ||
| rad1 | RAD17 | Exonuclease | RAD1 |
| rad3 | MEC1 | Lipid kinase domain | ATR, ATM |
| rad9 | DDC1 | G2 arrest | HRAD9 |
| rad17 | RAD24 | Nucleotide binding site | RAD17 |
| rad26 | none | S phase | None |
| chk1 (rad27)1-a | CHK1 | Kinase | CHK1 |
| rhp9 (crb2)1-a | RAD9 | DNA damage checkpoint | None |
| rad24/rad25 | BMH1-2 | Phosphoserine binding | 14-3-3 |
| hus1 | MEC3? | Rad1/rad9 interacting | HUS1 |
| cds1 | RAD53 | Kinase | CDS1/CHK2 |
↵1-a Allelic mutants are indicated in parentheses.