Table 2

Selected dosing amounts and duration for creatine supplementation

StudyDosageDurationApplication
Andrews et al. (1998) 4 × 5 g/day (20 g/day)5 daysCongestive heart failure
Dechent et al. (1999) 4 × 5 g/day4 weeksIncrease brain Cr
Hagenfeldt et al. (1994) 2 × 5 g/day (10 g/day)2 weeksMELAS
2 × 2 g/day maintenance
Heinanen et al. (1999) 1.5–2 g/day8–15 yearsGyrate atrophy
Hultman et al. (1996) 3 g/day>30 daysExercise performance
Recreational use4 × 5 g/day (20 g/day, 0.3 g kg−1)4–6 daysExercise performance
3–5 g/day maintenanceVaries
Tarnopolsky et al. (1997) 2 × 5 g/day (10 g/day)2 weeksMitochondrial cytopathies
2 × 2 g/day (4 g/day) maintenance1 week
Tarnopolsky et al. (1999) 10 g/day5 daysNeuromuscular Disease
5 g/day maintenance5–7 days
Vannas-Sulonen et al. (1985) 3 × 0.5 g/day (1.5 g/day) (adults)5 yearsGyrate atrophy
3 × 0.25 g/day (0.75 g/day) (children)
Volek et al. (1999) 5 × 5 g/day (25 g/day)7 daysExercise performance
5 g/day maintenance11 weeks
Vorgerd et al. (2000) 150 mg kg−1 (∼10 g/day)1 weekMyophosphorylase deficiency
60 mg kg−1 (∼3 g/day) maintenance4 weeks
Walter et al. (2000) 10 g/day (adults)8 weeksVarious muscular dystrophies
5 g/day (children)
Willer et al. (2000) 20 g/day5 daysRheumatoid arthritis
2 g/day maintenance16 days