Peroxynitrite biochemical impact
| Mechanism of Action | Action | Tissue |
|---|---|---|
| Oxidation | Surfactant damage | Lung |
| Peroxidation | Lipid damage | Various |
| Oxidation | Glutathione depletion | Various |
| Alteration SH-groups | Mitochondrial respiration inhibition | Various |
| Nitrotyrosine formation | SOD inhibition | Neurons |
| Nitrotyrosine formation | DOPA synthesis inhibition | Neurons |
| Oxidation, deamination, nitrosilation | DNA damage | Various |
DOPA, 3,4-dihydroxyphenylalanine.