Family Name | Size (kDa) | Polypeptide Variants | Tissue Distribution1-a | Covalent Modification | Activators | Inactivators |
---|---|---|---|---|---|---|
GRK1 (rhodopsin kinase) | 63 | N.D. | Retina (ROS) > pineal | Farnesylation | Polycations | Recoverin |
GRK2 (βARK1) | 79 | N.D. | pbl > cx > h > lu > k | N.D. | Gβγ, PIP2, PKC, c-Src | MAPK |
GRK3 (βARK2) | 80 | N.D. | olf > b > s > h > lu > k | N.D. | Gβγ, PIP2 | N.D. |
GRK4 | 66 | Four | t >>> b | Palmitoylation | N.D. | N.D. |
GRK5 | 68 | N.D. | h, lu > sk > b,l > k | N.D. | Polycations, PIP2 | PKC, calmodulin |
GRK6 | 66 | Yes | b, sk ≫ h, lu, k > l | Palmitoylation | Polycations | N.D. |
GRK7 | 62 | N.D. | Retina (cone) | N.D. | N.D. | N.D. |
(Farnesylation?) |
N.D., not determined.
↵1-a As determined by mRNA expression:b, brain; cx, cerebral cortex; h, heart; l, liver; lu, lung; k, kidney;olf, olfactory tubercle; pbl, primary blood leukocytes; s, spleen; sk, skeletal muscle;t, testes. PIP2, phosphatidylinositol 4,5-bisphosphate; ROS, rod outer segment.
References used: Arriza et al., 1992; Inglese et al., 1992; Pitcher et al., 1992, 1995, 1999; Benovic and Gomez, 1993; Dawson et al., 1993;Kunapuli and Benovic, 1993; Parruti et al., 1993a; Kunapuli et al., 1994; Premont et al., 1994, 1996; Stoffel et al., 1994; Touhara et al., 1994; Chuang et al., 1995; Winstel et al., 1996; Stoffel et al., 1998;Weiss et al., 1998; Iacovelli et al., 1999; Sarnago et al., 1999;Elorza et al., 2000.