17β-Estradiol concentrations in breast tumors, normal and benign breast tissues, and in sera
| Study | Mean ± S.D./S.E. (nM)3-b | Range (nM) |
|---|---|---|
| Intratumor concentrations of 17β-estradiol3-a | ||
| Bonney et al., 1983 (n = 13) | 1.76 ± 0.3 | |
| de Jong et al., 1997(n = 9) | 0.84 ± 0.58 | 0.148–1.77 |
| Drafta et al., 1983 (n = 41) | ER+ = 1.58 ± 1.06; ER− = 0.56 ± 0.393-c | |
| Edery et al., 1981(n = 78) | ER+ = 2.92 ± 1.29; ER− = 0.94 ± 1.033-d | |
| Fishman et al., 1977(n = 129) | ER+ = 0.33 ± 0.21; ER− = 0.19 ± 0.143-e | |
| Maynard et al., 1978 | N.D. | ER+ = 0–1.1; ER− = 0–0.24 |
| Mehta et al., 1987(n = 65) | 1.34 ± 0.13 | |
| Millington, 1975(n = 18) | 3.1 ± 11.97 | 0.7 nM–5.5 μM |
| Mistry et al., 1986 (n = 16) | 0.756 ± 0.49 | |
| Pasqualini et al., 1996 (n = 34) | 1.4 ± 0.7 (postmenopausal) | |
| Recchione et al., 1995 (n = 34) | 0.169 (median value) | 0.033–0.775 |
| van Landeghem et al., 1985 (n = 105) | 0.62 ± 0.39 | 0.02–1.52 |
| Vermeulen et al., 1986(n = 50) | 1.64 ± 1.89 | 0.07–9.02 |
| Overall mean estimate = 1.28 nM | ||
| Normal and benign breast tissues | ||
| Kyo et al., 1999 | 0.625 ± 0.018 (adjacent normal tissue) | |
| Schaefer et al., 1995 | N.D. | 0.06–0.56 |
| Mehta et al., 1987 (n= 61) | 0.93 ± 0.10 (adjacent normal tissue) | |
| Pasqualini et al., 1997 (n = 15) | 1.0 ± 0.25 (fibroadenoma) | |
| Szymczak et al., 1998 (n = 30) | 0.203 ± 0.025 (adipose) | |
| Vermeulen et al., 1986 (n = 14) | 1.05 ± 0.9 (glandular tissue) | 0.15–2.76 |
| Overall mean estimate = 0.76 nM |
Where values are missing, they cannot be readily identified from the publication(s). N.D. = not detected.
↵3-a All values are nM unless otherwise indicated. Numbers in parentheses are the number of subjects in the study.
↵3-b Mean estimates are provided with either the standard deviation or standard error and are based on the data presented in the studies using the following conversions: (a) 1 g tissue weight ≅ 1 ml; and (b) 50 mg protein ≅ 1 g tissue weight.
↵3-c p < 0.01 for ER+ vs. ER− (Drafta et al., 1983).
↵3-d p < 0.001 for ER+ vs. ER− (Edery et al., 1981).
↵3-e p < 0.02 for ER+ vs. ER− (Fishman et al., 1977).