Table 4

Representative antiestrogen-resistant human breast cancer variants derived from ER+/PgR+ parental cells

ParentalVariantER/PgR4-aPhenotype4-b
MCF-7LY2 +/−E2-independent; TAM and ICI 164,384 cross-resistant
MCF-7R27 +/?TAM-resistant
MCF-7RR +/?E2-independent; TAM-resistant
MCF-7MCF7/LCC1 +/+ E2-independent; antiestrogen-responsive
MCF7/LCC1MCF7/LCC2 +/+ E2-independent; TAM-resistant/ICI 182,780-responsive
MCF7/LCC1MCF7/LCC9 +/+ E2-independent; TAM and ICI 182,780 cross-resistant
MCF-7MCF-WES +/+ E2-independent; TAM-stimulated, ICI 182,780-resistant
ZR-75-1ZR75/LCC3−/−E2-independent; TAM and ICI 182,780 cross-resistant
ZR-75-1ZR-75-9a1−/−E2-independent; TAM and ICI 182,780 cross-resistant
T47DT47Dco−/+ E2-independent; TAM and ICI 182,780 cross-resistant

  • ? = unknown or unclear.

  • ↵4-a  ER/PgR expression in variants.

  • ↵4-b  Citations for the cells and their phenotypes can be found in the text.