Kinase Pathway | Intermediate/G-protein | Functional Response | Cell Type | References |
---|---|---|---|---|
p44 MAP kinase (ERK) | p21RAS/Gi/Go, tyrosine kinase | ND | Rat-1 fibroblasts | Van Corven et al., 1993 |
ND | p21RAS | AP-1/DNA synthesis | Astrocytoma cells | La Morte et al., 1993 |
p42/44 MAP kinase | SHC/GRB-2 | ND | CCL39 fibroblasts | Chen et al., 1996 |
p42/44 MAP kinase | RAF-1, tyrosine kinase | ND | NIH3T3 fibroblasts | Apostolidis and Weiss, 1997 |
ERK-5 | G12/G13/Gq | ND | COS-7 | Fukuhara et al., 2000 |
JNK/p38 MAP kinase | PKC | ND | HepG2 | Mitsui et al., 1998 |
pp60src | Gi/Go, Gq? | ND | CCL339 | Chen et al., 1994 |
pp72Syk | ND | ND | Platelets | Satoh et al., 1996 |
rasGAP | Fyn, Lyn Yes | ND | Platelets | Cichowski et al., 1992 |
SH-PTP-1, PTP1D | ND | Cytoskeleton, growth | Platelets, CCL39 cells | Rivard et al., 1995 |
p7056K | P-13 kinase, PKC, Gi/Go | DNA synthesis | Pulmonary artery fibroblasts, HTSM, BTSM | Belham et al., 1997; Krymskaya, et al., 1999; Walker et al., 1998 |
Protein kinase B | PI-3 kinase | DNA synthesis | BTSMC | Walker et al., 1998 |
PI-3 kinase | ND | Blebbling | CHRF-288 | Vemuri et al., 1996 |
PI-3 | Rho, βγ-subunits | ND | Platelets | Zhang et al., 1995 |
JAK-2/STAT-1 | ND | Inhibition of growth | Tumor cells | Huang et al., 2000 |
PYK-2 | Src, PKC | Aggregation | Platelets | Ohmori et al., 1999 |
ND | GEF/Rho/G12/G13 | Cell rounding | 1321N1 astrocytoma cells | Majumdar et al., 1999 |
Rho kinase | Rho | DNA synthesis/migration | RASMC | Seasholtz et al., 1999 |
pp125FAK | ND | ND | Glomerula mesangial cells | Choudhury et al., 1996 |
Kinase pathways activated following PAR-1 stimulation. Intermediates in all cases have not been identified and are partly based on other G-protein-coupled receptors. JAK-2, Janus-activated kinase-2; Src, cellular homology of the Src oncogene product; STAT-1, signal transducers and activator of transcrition-1; GAP, GTPase activating protein; SYK, spleen tyrosine kinase; PYK2, proline-rich tyrosine kinase 2; SH-PTP-1, Src homology domain containing protein tyrosine phosphatase-1; GEF, Rho G-protein nucleotide exchange factor; ND, not determined.