Table 2

Distribution of α₁-adrenoceptor subtypes in blood vessels

Species and Vessel	Receptor Subtype
Species and Vessel	mRNA or Protein	Functional	Reference
Mouse
AC01 cells^2-a		α_1D	Ohmi et al., 1999
Rat
Aorta	α_1A, α_1B, α_1D ^*	α_1D ^**	Hrometz et al., 1999 ^;Kenny et al., 1995 ^; Piascik et al., 1995 ^; Testa et al., 1995 ^*;
		α_1A, α_1B, α_1D ^***	Van der Graaf et al., 1996a ^***
Carotid artery		α_1D	Villalobos-Molina and Ibarra, 1996
Mesenteric artery	α_1A, α_1B, α_1D ^*	α_1D, α_1A, α_1B(?)^**	Hrometz et al., 1999 ^; Villalobos-Molina and Ibarra, 1996 ^; Lachnitt et al., 1997 ^; Piascik et al., 1997 ^*
Tail artery	α_1A, α_1B, α_1D ^*	α_1A ^**	Hrometz et al., 1999 ^;Lachnit et al., 1997 ^; Piascik et al., 1997 ^*
Renal artery	α_1B > α_1D > α_1A ^*	α_1A, α_1D ^**	Hrometz et al., 1999 ^; Han et al., 1990 ^;Piascik et al., 1997 ^*
Iliac artery	α_1A, α_1B, α_1D ^*	α_1D ^**	Hrometz et al., 1999 ^; Piascik et al., 1997 ^*
Femoral artery	α_1B > α_1A > α_1D ^*	α_1D ^**	Hrometz et al., 1999 ^; Piascik et al., 1997 ^; Hrometz et al., 1999 ^*
Pulmonary artery		α_1D	Hussain and Marshall, 1997
Mesenteric resistance arteries	α_1A, α_1B, α_1D ^*	α_1B ^**	Hrometz et al., 1999 ^; Van der Graaf et al., 1996b ^; Piascik et al., 1997 ^*
Skeletal muscle arteries		α_1D(α_2D)	Leech and Faber, 1996
Skeletal muscle veins		α_1B, α_1D	Leech and Faber, 1996
Vena cava		α_1B	Sayet et al., 1993
Guinea pig
Aorta		α_1L	Yamamoto and Koike 1999
Nasal mucosa vasculature		α_1A (α_1L) (?)	Tanimitsu et al., 2000
Rabbit
Thoracic aorta		α_1A, α_1D, α_1B, α_1L	Takayanagi et al., 1991; Fagura et al., 1997;Muramatsu et al., 1998
Carotid artery		α_1L	Muramatsu et al., 1990
Abdominal aorta		α_1A, α_1B	Satoh et al., 1999
Iliac artery		α_1D, α_1A, α_1B	Satoh et al., 1999
Mesenteric artery		α_1L, α_1D	Van der Graaf et al., 1997; Satoh et al., 1999
Renal artery		α_1D, α_1A, α_1B	Satoh et al., 1999
Ear artery		α_1A, α_1D (?)	Fagura et al., 1997
Cutaneous resistance arteries		α_1B, α_1L	Smith et al., 1997
Dog
Aorta		α_1B	Low et al., 1998
Lingual artery		α_1A	Skrbic and Chiba, 1992
Mesenteric artery		α_1A	Daniel et al., 1999
Subcutaneous resistance arteries		α_1A/α_1L	Argyle and McGrath, 2000
Saphenous vein		α_1A	Hicks et al., 1991
Pig
Coronary artery		α_1A	Yan et al., 1998
Human
Aorta	α_1D		Rudner et al., 1999
Carotid artery	α_1A		Rudner et al., 1999
Femoral artery	α_1A > α_1D		Rudner et al., 1999
Iliac artery	α_1A		Rudner et al., 1999
Mammary artery	α_1A > α_1B > α_1D		Rudner et al., 1999
Celiac artery	α_1A > α_1B		Rudner et al., 1999
Hepatic artery	α_1A		Rudner et al., 1999
Mesenteric artery	α_1A ≫ α_1B		Rudner et al., 1999
Splenic artery	α_1A > α_1B		Rudner et al., 1999
Omental artery	α_1A > α_1B, α_1D		Rudner et al., 1999
Renal artery	α_1A > α_1B		Rudner et al., 1999
Pulmonary artery	α_1A > α_1B, α_1D		Rudner et al., 1999
Right coronary artery	α_1A		Rudner et al., 1999
Left coronary artery	α_1A		Rudner et al., 1999
Circumflex artery	α_1A		Rudner et al., 1999
Lingual artery		α_1A, α_1B	Skrbic and Chiba, 1992
Iliac vein	α_1A, α_1B, α_1D		Rudner et al., 1999
Vena cava	α_1A ≫ α_1D		Rudner et al., 1999
Saphenous vein	α_1A, α_1B		Rudner et al., 1999
Omental vein	α_1A		Rudner et al., 1999
Renal vein	None		Rudner et al., 1999
Pulmonary vein	α_1A > α_1B > α_1D		Rudner et al., 1999
Prostate vessels		α_1A(α_1L) (?)	Marshall et al., 1995

↵2-a A novel vascular smooth muscle cell line cloned from p53 knockout mice (Ohmi et al., 1999).