Table 5
α2A/Dα2Bα2C
Dog saphenous vein r = 0.905-150 r = 0.78 r = 0.855-150
Slope = 0.955-150 Slope = 0.41Slope = 0.895-150
Human gastric artery r = 0.945-150 r = 0.66 r = 0.71
Slope = 1.285-150 Slope = 0.615-150 Slope = 0.88
Human ileocolic artery r = 0.965-150 r = 0.68 r = 0.57
Slope = 1.395-150 Slope = 0.77Slope = 0.88
  • Correlation between pEC30% values of antagonists at prejunctional α2-autoreceptors of the canine saphenous vein (Paiva et al., 1997), and human gastric and iliocolic arteries (Guimarães et al., 1998b) and pK i values at binding sites (HT29 cells, in A; neonatal rat lung, in B; OK cells, in C; and rat submaxillary gland, in D).

  • 5-150p < 0.05.