P-glycoprotein | Human | Species | Tissue Specificity | |
---|---|---|---|---|
Mouse/Rat | Hamster | |||
Class I | MDR1 | mdr1a | pgp1 | Intestine, brain (BBB, astrocytes, microglia), heart, and kidney |
Class II | MDR1 | mdr1b | pgp2 | Gravid mouse uterus, adrenal gland, kidney, heart, and brain (astrocytes, microglia) |
Class III | MDR3 or MDR2 | mdr2 | pgp3 | Liver, adrenal gland, spleen, heart, and muscle |
pgp, P-glycoprotein. In general, class I and II substrates include organic cations and lipophilic compounds whereas class III substrates are primarily phospholipids (Ford, 1995;Schinkel, 1997).