Saturation analysis of 125I-[Tyr14]OFQ/N and125I-[Tyr11]OFQ/N(1–11) binding in transfected CHO cells and mouse brain
| Radioligand | NOP1/CHO Cells | Mouse Brain | |
|---|---|---|---|
| KD (pM) | KD(pM) | Bmax (fmol/mg protein) | |
| 125I-[Tyr10]OFQ/N(1–11) | 2700 ± 700 | 235 ± 7.8 | 43.2 ± 4.6 |
| 125I-[Tyr14]OFQ/N | |||
| Site 1 | 37 ± 2 | 3.8 ± 3.3 | 32 ± 18 |
| Site 2 | Not applicable | 896 ± 636 | 233 ± 154 |
Data adapted from Mathis et al., 1999.