Table 2

Presynaptic nucleotide receptors mediating modulation of noradrenaline release from sympathetic neurons

Species	Tissue	Effect of Receptor Activation	Receptor Subtype	Agonists	Antagonists	Drugs without Effect	Reference
Rat	Mesenteric artery	Inhibition	P2	β,γ-MeATP^2-a	DPCPX^2-b		Shinozuka et al., 2001
				2MeSATP^2-c	PPADS^2-d
Guinea pig	Atrium	Stimulation	P2X3	ATP	PPADS	Reactive blue 2	Sperlagh et al., 2000
		Facilitation		2MeSATP	Suramin
				α,β-MeATP^2-e	TNP-ATP^2-f
				β,γ-MeATP
				ADP
Rat	Cultured sympathetic neurons	Stimulation	P2X	ATP	Suramin	DIDS	von Kugelgen et al., 1999b
					Cibacron blue 3GA
Rat	Cultured sympathetic neurons	Stimulation	P2X2	ATP	Suramin	ADP	Boehm, 1999
		Facilitation		2MeSATP	PPADS	UDP
				ATPγS^2-g		α,β-MeATP
						β,γ-MeATP
Rabbit	Ear artery	Facilitation	P2Y	β,γ-MeATP			Ishii-Nozawa et al., 1999
Rat	Pancreas	Inhibition	P2Y	ATP	Cibacron blue 3GA	PPADS	Koch et al., 1998
				ATPγS	Reactive blue 2
				ADPβS	Reactive red 2
Rat	Kidney	Inhibition	P2Y	ATPγS	Cibacron blue 3GA	Suramin	Bohmann et al., 1997
Rat	Tail artery	Inhibition	P2Y	2MeSATP	Cibacron blue 3GA		Goncalves and Queiroz, 1996
					Suramin
Rabbit	Ear artery	Facilitation	Neither P1 nor P2	β,γ-MeATP	α,β-MeATP		Ishii et al., 1995
				ATP
				2MeSATP
Rat	Atrium	Inhibition	P2Y	ATPγS	Cibacron blue 3GA	β,γ-Me-l-ATP	von Kugelgen et al., 1995
				ATP
Chicken	Sympathetic neurons	Facilitation	P2	ATP	Reactive blue 2		Allgaier et al., 1995a
				2MeSATP	Suramin
		Inhibition	P2	ATP	Suramin	Reactive blue 2
Chicken	Sympathetic neurons	Inhibition	P2	ATP	Suramin		Allgaier et al., 1994a
		Facilitation	P2Y	2MeSATP	Suramin	α,β-MeATP
Rabbit	Vas deferens	Inhibition	P3	ATP	α,β-MeATP		Todorov et al., 1994
				β,γ-MeATP
				Adenosine
				2-Chloroadenosine
	Saphenous artery	Facilitation	P3	ATP	8-SPT^2-h	α,β-MeATP
				β,γ-MeATP
				Adenosine
				2-Chloroadenosine
Mouse	Vas deferens	Inhibition	P2Y	ATPγS	Reactive blue 2		von Kugelgen et al., 1994b
					Brilliant blue G
					Suramin
					PPADS
Rat	Vas deferens	Inhibition	P2Y		Reactive blue 2
					Brilliant blue G
					Suramin
Mouse	Vas deferens	Inhibition	P2Y	α,β-MeATP	Suramin		Kurz et al., 1993
				β,γ-MeATP
				2MeSATP
Rat	Vas deferens	Inhibition	P2Y	α,β-MeATP	Suramin
				β,γ-MeATP
				2MeSATP
Rat	Iris	Inhibition	P2Y	ATP	Reactive blue	Suramin	Fuder and Muth, 1993
					α,β-MeATP	DIDS
Mouse	Vas deferens	Inhibition	P2Y		Suramin		von Kugelgen et al., 1993
					Reactive blue 2
Rabbit	Ear artery	Facilitation	P2	ATP	Suramin		Ishii et al., 1993
Rat	Iris	Inhibition	P2	ATP		UTP	Fuder et al., 1992
Rat	Vas deferens	Inhibition	P3	2-Chloroadenosine	8-SPT		Forsyth et al., 1991
				ATP	α,β-MeATP
				β,γ-MeATP
				UTP
Guinea pig	Ileum	Facilitation	P2X	α,β-MeATP			Sperlagh and Vizi, 1991
Rat	Caudal artery	Inhibition	P3	2-Chloroadenosine	α,β-MeATP		Shinozuka et al., 1990
				β,γ-MeATP
Mouse	Vas deferens	Inhibition	P2Y	ATPγS		α,β-MeATP	von Kugelgen et al., 1989
				ATP		Uridine
				UTP
Rat	Caudal artery	Inhibition	P3	2-Chloroadenosine	8-SPT		Shinozuka et al., 1988
				β,γ-MeATP
				ATP
				Adenosine
Rabbit	Ear artery	Facilitation	P2	ATP	α,β-MeATP		Miyahara and Suzuki, 1987
				AMP-PNP^2-i

↵2-a β,γ-MeATP, β,γ-methylene ATP.
↵2-b DPCPX, 1,3-dipropyl-8-cyclopentylxanthine.
↵2-c 2MeSATP, 2-methylthio-ATP.
↵2-d PPADS, pyridoxalphosphate-6-azophenyl-2′,4′-disulfonic acid.
↵2-e α,β-MeATP, α,β-methylene ATP.
↵2-f TNP-ATP, 2′-o-(trinitrophenyl)-adenosine 5′-triphosphate.
↵2-g ATPγS, adenosine 5′[γ-thio]triphosphate.
↵2-h 8-SPT, 8-(p-sulfophenyl)-theophylline.
↵2-i AMP-PNP, adenosine 5′-[β,γ-imino]triphosphate.