Table 4

Presynaptic adenosine receptors mediating modulation of sympathetic transmitter release

SpeciesTissueParameter DeterminedDrug without EffectEffect of Receptor ActivationReceptor SubtypeReference
RatMesenteric arteryNA releaseInhibitionA1 Shinozuka et al., 2001
Guinea pigVas deferensejpInhibitionA1 Hardy and Brock, 1999
RatPancreasNA releaseCGS 21680InhibitionA1 Koch et al., 1998
RatHeartNA releaseCPCAInhibitionA1 Snyder et al., 1998
RabbitIris/ciliary bodyNA releaseCV1808InhibitionA1 Crosson and Gray, 1997
RatSCG neuronsNA releaseInhibitionP1 Koh and Hille, 1997
HumanAtriumNA releaseInhibitionP1 Munch et al., 1996
RabbitEar arteryNA releaseFacilitationP1 Ishii et al., 1996
RatTail arteryNA releaseInhibitionA1 Goncalves and Queiroz, 1996
FacilitationA2A
RatCaudal arteryNA releaseInhibitionP1 Shinozuka et al., 1995
DogPulmonary arteryNA releaseInhibitionA1 Vaz-da-Silva et al., 1995
Guinea pigAtriumNA releaseCGS 21680InhibitionA1 Nakatsuka et al., 1995
RatThymusNA releaseInhibitionP1 Hasko et al., 1995
Guinea pigVas deferensNA and ATP release and neurogenic contractionInhibitionA1 Driessen et al., 1994
RabbitEar arteryNA releaseFacilitationA1 Maynard and Burnstock, 1994
MouseVas deferensNA releaseInhibitionA1 Kurz et al., 1993
RatVas deferensNA releaseInhibitionA1

  • NA, noradrenaline; ejp, excitatory junction potential; CGS 21680, 2-p-(2-carboxyethyl)-phenethylamino-5′-N-ethylcarboxamido-adenosine; CPCA, cyclopropylcarboxamidoadenosine; CV1808, 2-phenylaminoadenosine.