Table 2

Amino acid sequences of the human ET_A and ET_Breceptors

ET_A	`M-------------------------------------------------ETLCLRASF`
ET_B	`MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRA----TP- LLQTAEIMTPPTKTL`
ET_A	`WLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYC`
ET_B	`W-----------PKGSNASLARSLAPAEVPKGDR----TAGSPPRTISPPP-------C`
	`I`
ET_A	`PQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLI`
ET_B	`QGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLL`
	`II III`
ET_A	`YVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAV`
ET_B	`HIVIDIPINVYKLLAEDWPFGAE-----MCKLVPFIQKASVGITVLSLCALSIDRYRAV`
	`IV`
ET_A	`ASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCMLNATSK`
ET_B	`ASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRICLLHPVQK`
ET_A	`--FMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRRE`
ET_B	`TAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEML-RKKSGMQIALNDHLKQRRE`
	`VI VII`
ET_A	`VAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNS`
ET_B	`VAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNS`
ET_A	`CINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSS`
ET_B	`CINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNK`
ET_A	`HKDSMN`
ET_B	`YSSS`