Table 1

The chemokine receptor family

NameReceptor CodeSWISSPROTMain AgonistsMain Functions
CXC subgroup
 CXCR12.1:CHK:1:CXC1: P25024 CXCL8Neutrophil migration; innate immunity; acute inflammation
 CXCR22.1:CHK:2:CXC2: P25025 CXCL1–3; CXCL5–8Neutrophil migration; innate immunity; acute inflammation; angiogenesis
 CXCR32.1:CHK:3:CXC3: P49682 CXCL9–11T cell migration; adaptive immunity; Th1 inflammation
 CXCR42.1:CHK:4:CXC4: P30991 CXCL12B cell lymphopoiesis; bone marrow myelopoiesis; central nervous system and vascular development; HIV infection
 CXCR52.1:CHK:5:CXC5: P32302 CXCL13B cell trafficking; lymphoid development
 CXCR62.1:CHK:19:CXC6: O00574 CXCL16T cell migration
CC subgroup
 CCR12.1:CHK:6:CC1: P32246 CCL3, CCL5, CCL7, CCL8, CCL13–16, CCL23T cell and monocyte migration; innate and adaptive immunity; inflammation
 CCR22.1:CHK:7:CC2: P41597 CCL2, CCL7, CCL8, CCL13T cell and monocyte migration; innate and adaptive immunity; Th1 inflammation
 CCR32.1:CHK:8:CC3: P51677 CCL5, CCL7; CCL8; CCL11, CCL13; CCL15; CCL24; CCL26Eosinophil, basophil, and T cell migration; allergic inflammation
 CCR42.1:CHK:9:CC4: P51679 CCL17, CCL22T cell and monocyte migration; allergic inflammation
 CCR52.1:CHK:10:CC5: P51681 CCL3; CCL4; CCL5; CCL8, CCL14T cell and monocyte migration; innate and adaptive immunity; HIV infection
 CCR62.1:CHK:11:CC6: P51684 CCL20Dendritic cell migration
 CCR72.1:CHK:12:CC7: P32248 CCL19, CCL21T cell and dendritic cell migration; lymphoid development; primary immune response
 CCR82.1:CHK:13:CC8: P51685 CCL1, CCL4; CCL17T cell trafficking
 CCR92.1:CHK:14:CC9: P51686 CCL25T cell homing to gut
 CCR102.1:CHK:15:CC10: P46092 CCL26–28T cell homing to skin
CX3C and C subgroups
 CX3CR12.1:CHK:17:CX3C1 P49238 CX3CL1T cell and NK cell trafficking and adhesion; innate and adaptive immunity; Th1 inflammation
 XCR12.1:CHK:18:XC1: P46094 XCL1–2T cell trafficking