Table 1

Structures CGRP, amylin, adrenomedullin, and calcitonin

hαCGRP A C   D T A T C V T H R L A G L L S R S G G V V K N N F V P T N V G S K A   F
rαCGRP S C   N T A T C V T H R L A G L L S R S G G V V K D N F V P T N V G S E A   F
hβCGRP A C   N T A T C V T H R L A G L L S R S G G M V K S N F V P T N V G S K A   F
rβCGRP S C   N T A T C V T H R L A G L L S R S G G V V K D N F V P T N V G S K A   F
hAMY K C   N T A T C A T Q R L A N F L V H S S N N F G A I L S S T N V G S N T   Y
rAMY K C   N T A T C A T Q R L A N F L V R S S N N L G P V L P S T N V G S N T   Y
hAM G C   R F G T C T V Q K L A H Q I Y Q F T D K D K D N V A P R N K I S P Q G Y
rAM G C   R F G T C T M Q K L A H Q I Y Q F T D K D K D G M A P R N K I S P Q G Y
hCT   C G N L S T C M L G T Y T Q D F N K F H T F           P Q T A I G V G A   P
sCT   C S N L S T C V L G K L S Q E L H K L Q T Y           P R T N T G S G T   P
  ____________   _ _ _ _ _ _ _ _ _ _ _
   Disulfide bond         α-helix
  • h, human; r, rat; s, salmon.

  • hAM is the structure of the 15–52 fragment; the N-terminal amino acids are YRQSMNNFQGLRSF. rAM shows the structure of the 13–50 fragment; the N-terminal amino acids are YRQSMNQGSRST.