Table 4

Pharmacological profile of human receptors in the presence and absence of human RAMPs

ReceptorhCTsCTrAMYh╬▒CGRPCellReferences
hCT(b)receptor 9.45/6.89 10.56/6.936.586.77COS-7 Tilakaratne et al., 2000
10.93/6.7811.06/8.12 10.0/5.65 11.08/5.77 CHO-P Tilakaratne et al., 2000
hCT(b)receptor/hRAMP16.9410.98/9.29 10.95/8.43 9.93/7.94COS-7 Tilakaratne et al., 2000
9.89/6.95 11.2/6.4111.29/8.6611.89/8.64 CHO-P Tilakaratne et al., 2000
hCT(b)receptor/hRAMP27.9511.06/9.33 10.67/8.23 10.87/7.72 COS-7 Tilakaratne et al., 2000
9.63/6.42 11.83/8.8310.65/7.59 10.96/7.7 CHO-P Tilakaratne et al., 2000
hCT(b)receptor/hRAMP36.8711.06/9.1611.03/8.19 8.9/7.1COS-7 Tilakaratne et al., 2000
10.19/5.95 11.53/8.8911.55/8.210.1/6.9CHO-P Tilakaratne et al., 2000
hCT(a)receptor7.819.036.27>6COS-7Zumpe et al., 1999
6.3>6RAEC Muff et al., 1999
11.12/6.45 11.96/8.086.079.94/5.78CHO-P Tilakaratne et al., 2000
hCT(a)receptor/hRAMP16.929.058.277.87COS-7 Christopoulos et al., 1999
7.539.518.17.67COS-7Zumpe et al., 1999
8.57.85RAEC Muff et al., 1999
9.79/5.97 12.19/9.0011.9/8.03 8.9/6.03CHO-P Tilakaratne et al., 2000
hCT(a)receptor/hRAMP28.089.897.825.86COS-7Zumpe et al., 1999
No evidence of coupling; wild-type phenotypeRAEC Muff et al., 1999
8.94/5.92 12.19/8.548.137.64CHO-P Tilakaratne et al., 2000
hCT(a)receptor/hRAMP37.719.688.26.82COS-7Zumpe et al., 1999
8.406.59RAEC Muff et al., 1999
11.11/6.02 12.12/8.2911.7/7.78 10.96/6.79 CHO-P Tilakaratne et al., 2000
  • Values represent pIC50 values obtained against125I-AMY or 125I-sCT. Where two sites were detected, the sites highlighted in bold were present at >60%.