Table 6

Genomics of the CT/CGRP/AM/AMY family and their receptors

Receptor/PeptideHUGO gene NameAccession NumberHuman Chromosomal Location
CT receptorCALCRSWMain:P309887q21.3
CL receptorCALCRLSWMain:Q166022q32.1
RAMP1RAMP1SWMain:O608942q37.3
RAMP2RAMP2SWMain:O6089517q21.2
RAMP3RAMP3SWMain:O608967p13
CT/αCGRPCALCASWMain:P0125811p15.2
SWMain::P06881
βCGRPCALCBSWMain:P1009211p15.2
AMADMSWMain:P3531811p15.2
AMYIAPPSWMain:P1099712p12.1
  • HUGO, human genome organization; IAPP, islet amyloid polypeptide.

  • The CALCA, CALCB, and ADM genes are within a 5-megabase region on chromosome 11p15, with CALCA and CALCB adjacent to each other. This is almost certainly the result of gene duplication.