Efficacy of antioxidants in the treatment of cerebral ischemia and intracranial hemorrhage in clinical studies
| Antioxidant | Disease | Efficacy | References |
|---|---|---|---|
| Vitamins (mainly E, C, carotenoids (β-carotene), and flavonoids | Ischemic stroke | + | Gey et al., 1993; Keli et al., 1996; Daviglus et al., 1997 |
| − | Blot et al., 1993;Hennekens et al., 1996 | ||
| +/− | Yochum et al., 2000 (just from food) | ||
| Ebselen | + | Yamaguchi et al., 1998 | |
| + | Ogawa et al., 1999 | ||
| SAH | − | Saito et al., 1998 | |
| Tirilazad mesylate | SAH | + | Kassel et al., 1996 |
| − | Haley et al., 1997 | ||
| Head injury | − | Marshall et al., 1998; Maas et al., 1999 | |
| Spinal cord injury | − | Bracken et al., 1997 | |
| Superoxide dismutase-like | Head injury | − | Young et al., 1996 |
| Nicaraven | SAH | + | Asano et al., 1996 |