Table 6

Cooperativity factors for the allosteric modulator, alcuronium, at the M2 muscarinic acetylcholine receptor

Orthosteric Ligand1/α
Agonists6-a
 Arecoline1.7
 Acetylcholine10
 Bethanecol10
 Carbachol9.5
 Furmethide8.4
 Methylfurmethide7.3
Antagonists
 Atropine6-b 0.26
 Methyl-N-piperidinyl benzilate6-b 0.54
 Methyl-N-quinuclidinyl benzilate6-b 63
 Methyl-N-scopolamine6-c 0.24

  • ↵6-a  Data fromJakubı́k et al., 1997.

  • ↵6-b  Data from Hejnova et al., 1995.

  • ↵6-c  Data from Proska and Tucek, 1994.