Caveolar Localization | M | B | Interact with Caveolins | References |
---|---|---|---|---|
G-protein-coupled receptors: | ||||
β1 and β2 adrenergic receptor | + | + | + | Schwencke et al., 1999; Ostrom et al., 2000b; Rybin et al., 2000 |
Bradykinin B2 receptor | + | + | Haasemann et al., 1998;Ju et al., 2000 | |
Endothelin type A | + | + | + | Chun et al., 1994; Okamoto et al., 2000 |
Cholecystokinin | + | Roettger et al., 1995 | ||
m-2 acetylcholine | + | Rybin et al., 2000 | ||
Ca2+-sensing receptor | + | Kifor et al., 1998 | ||
Adenosine A(1) receptor | + | Lasley et al., 2000 | ||
G-proteins | ||||
Gαs | + | + | Donati et al., 2001; Li et al., 1996a; Lisanti et al., 1994b; Rybin et al., 2000 | |
Gαi1 | + | + | Lisanti et al., 1994b; Li et al., 1996a; Song et al., 1997a; Rybin et al., 2000 | |
Gαi2 | + | + | Lisanti et al., 1994b; Li et al., 1996a; Rybin et al., 2000 | |
Go | + | Li et al., 1996a | ||
Gβγ | + | Lisanti et al., 1994b; Schwencke et al., 1999 | ||
Gq | + | Lisanti et al., 1994b;Pike and Miller, 1998; Oh and Schnitzer, 2001 | ||
Membrane proteins | ||||
Insulin receptor | + | + | Yamamoto et al., 1998;Gustavsson et al., 1999; Nystrom et al., 1999 | |
PDGF receptor | + | + | + | Liu et al., 1996b; Yamamoto et al., 1999 |
EGF receptor | + | Mineo et al., 1996,1999 | ||
VEGF receptor | + | + | Feng et al., 1999 | |
p75 NGF receptor | + | + | Bilderback et al., 1997;Huang et al., 1999 | |
Trk A | + | Huang et al., 1999 | ||
c-Neu | + | Engelman et al., 1998b | ||
TGFβ type I and II receptors | + | + | + | Razani et al., 2001b |
RAGE | + | + | Schmidt et al., 1992; Lisanti et al., 1994b; Stitt et al., 2000 | |
GLUT-4 | + | + | Scherer et al., 1994; Gustavsson et al., 1996; Ros-Baro et al., 2001 | |
Ca+ 2-ATPase | + | Tachibana and Nawa, 1992; Fujimoto, 1993; Schnitzer et al., 1995c | ||
H+-ATPase | + | Mineo and Anderson, 1996 | ||
TFPI (Tissue Factor Pathway inhibitor) | + | + | Lupu et al., 1997;Crawley et al., 2000 | |
Flotillin-1 and -2 | + | + | Bickel et al., 1997; Volonte et al., 1999 | |
AMR-R (Autocrine motility factor receptor) | + | Benlimame et al., 1998 | ||
PV-1 | + | Stan et al., 1999 | ||
P-glycoprotein | + | + | Demeule et al., 2000 | |
L-type Ca2+channel | + | + | Darby et al., 2000;Daniel et al., 2001 | |
Plasma membrane Ca2+ pump | + | + | Darby et al., 2000 | |
Kv1.5 voltage-gated K+channel | + | + | Martens et al., 2001 | |
Membrane-type 1 matrix metalloproteinase (MT1-MMP) | + | Annabi et al., 2001 | ||
Apolipoprotein E receptor 2 (apoER2) | + | Riddell et al., 2001 | ||
CD48 (GPI) | + | + | Shin et al., 2000 | |
Nonreceptor tyrosine kinases | ||||
Src | + | + | Sargiacomo et al., 1993;Li et al., 1996a | |
Fyn | + | + | + | Sargiacomo et al., 1993;Shenoy-Scaria et al., 1994; Li et al., 1996a |
Yes | + | Sargiacomo et al., 1993 | ||
Lck | + | Lisanti et al., 1994b; Shenoy-Scaria et al., 1994 | ||
Hck | + | Robbins et al., 1995a; b | ||
Lyn | + | Lisanti et al., 1994b | ||
JAK2 | + | Lisanti et al., 1994b | ||
Tyk2 | + | Ju et al., 2000 | ||
STAT3 | + | Ju et al., 2000 | ||
Nonreceptor Ser/Thr kinases | ||||
PKA | + | + | + | Razani et al., 1999 |
Raf | + | Mineo et al., 1996 | ||
MEK | + | Engelman et al., 1998a | ||
ERK | + | Engelman et al., 1998a | ||
PI 3-kinase | + | + | Lisanti et al., 1994b; Zundel et al., 2000 | |
GRK | + | + | Carman et al., 1999 | |
PKCα, δ, ɛ | + | Lisanti et al., 1994b; Kifor et al., 1998; Rybin et al., 1999 | ||
Other enzymes | ||||
Adenylyl cyclase | + | + | Fagan et al., 2000; Ostrom et al., 2000b; Rybin et al., 2000 | |
eNOS | + | + | + | Garcia-Cardena et al., 1996b, 1997; Liu et al., 1996a; Shaul et al., 1996 |
nNOS | + | + | Venema et al., 1997; Daniel et al., 2001 | |
Phopholipase D2 | + | + | Czarny et al., 1999 | |
Phospholipase C-γ1 | + | + | Jang et al., 2001 | |
Prostacyclin synthase (PGI2) | + | + | + | Spisni et al., 2001 |
Cyclooxygenase-2 (COX-2) | + | + | + | Liou et al., 2001 |
GTPases | ||||
H-Ras | + | + | + | Mineo et al., 1996;Song et al., 1996a; Prior et al., 2001 |
Rap1 | + | Chang et al., 1994;Lisanti et al., 1994b | ||
Rap2 | + | Lisanti et al., 1994b | ||
RhoA | + | + | Gingras et al., 1998 | |
Cdc42 | + | Gingras et al., 1998 | ||
Cellular proteins/adaptors | ||||
PIP, PIP2 | + | + | Pike and Casey, 1996; Pike and Miller, 1998; Waugh et al., 1998 | |
Shc | + | + | Lisanti et al., 1994b;Smith et al., 1998; Wary et al., 1998 | |
SOS | + | Smith et al., 1998 | ||
GRB2 | + | Lisanti et al., 1994b;Smith et al., 1998 | ||
IRS-1 | Smith et al., 1998 | |||
E-cadherin | + | + | + | Galbiati et al., 2000a |
β-catenin | + | + | + | Galbiati et al., 2000a |
γ-catenin | + | + | + | Galbiati et al., 2000a |
Calsequestrin | + | + | + | Darby et al., 2000; Daniel et al., 2001 |
Calreticulin | + | + | + | Darby et al., 2000;Daniel et al., 2001 |
Nuclear proteins | ||||
Estrogen receptor | + | + | Schlegel et al., 1999b; Chambliss et al., 2000 | |
Androgen receptor | + | + | Lu et al., 2001 | |
Structural proteins | ||||
Actin | + | + | Chang et al., 1994;Lisanti et al., 1994b | |
Annexin II and IV | + | Sargiacomo et al., 1993;Lisanti et al., 1994b; Schnitzer et al., 1995b | ||
VAMP-2 | + | Schnitzer et al., 1995b; McIntosh and Schnitzer, 1999 | ||
SNARE | + | + | Schnitzer et al., 1995b;Predescu et al., 1997 | |
SNAP | + | Schnitzer et al., 1995b | ||
NSF | + | + | Schnitzer et al., 1995b;Predescu et al., 1997 | |
Dynamin | + | + | Predescu et al., 1997;Henley et al., 1998; Oh et al., 1998 | |
MAL | + | Millan et al., 1997a,b | ||
Other proteins | ||||
Atrial Natriuretic Peptide | + | Page et al., 1994 |
M, morphological evidence; B, biochemical evidence.