Table 1

Mammalian RGS proteins: general information and binding partners

Classification		Size^1-a	Identity^1-b	Gα Interactions		Other Binding Partners	References for Partners
Classification		Size^1-a	Identity^1-b	in Vivo	in Vitro	Other Binding Partners	References for Partners
RGS1	B/R4	196	87%	G_q; G_i/o	Gα_i/o
RGS2	B/R4	211	94%	G_q; G_i/o	Gα_q	Adenylyl cyclase^1-c; β-COP	Sinnarajah et al., 2001; Chen et al., 2001
RGS3	B/R4	519	77%	G_i/o; G_q; G_s	Gα_i; Gα_q	14-3-3; Gβγ	Benzing et al., 2000; Shi et al., 2001
RGS4	B/R4	205	97%	G_i/o; G_q	Gα_i/o; Gα_q	PLCβ; Gβγ; β-COP; PIP₃; Ca^2⁺ CaM	Tu et al., 2001; Dowal et al., 2001; Dowal et al., 2001; Popov et al., 2000;Sullivan et al., 2000
RGS5	B/R4	181	88%	G_i/o; G_q	Gα_i/o; Gα_q
RGS6	C/R7	437	87%		Gα_o	Gβ5	Cabrera et al., 1998; Snow et al., 1998b; Posner et al., 1999; Snow et al., 1999; Zhang and Simmonds, 2000; Liang et al., 2000
RGS7	C/R7	443	98%	G_q	Gα_i/o	Gβ5; polycystin; 14-3-3	Cabrera et al., 1998; Snow et al., 1998b; Posner et al., 1999; Snow et al., 1999; Zhang and Simmonds, 2000; Liang et al., 2000; Kim et al., 1999; Benzing et al., 2000
RGS8	B/R4	198	98%	G_i/o	Gα_i/o
RGS9-1/RGS9-2	C/R7	443/674	90%	G_i/o; G_t	Gα_t	Gβ5; γ-PDE; evectin	Makino et al., 1999; Slep et al., 2001; Chen et al., 2001
RGS10	D/R12	167	91%		Gα_i3; Gα_o; Gα_z
RGS11	C/R7	446	79%		Gα_o	Gβ5	Cabrera et al., 1998; Snow et al., 1998b; Posner et al., 1999; Snow et al., 1999; Zhang and Simmonds, 2000; Liang et al., 2000
RGS12	D/R12	1447	85%	G_12/13	Gα_i/o	IL8-R(CXCR2); N-type Ca^2⁺ channel; Gα_i-GDP	Snow et al., 1998a; Schiff et al., 2000; Kimple et al., 2001
RGS13	B/R4	159
RGS14	D/R12	544 (rat)	82%	G_12/13	Gα_i/o	Rap1,Rap2; Gαi-GDP	Traver et al., 2000; Kimple et al., 2001; Hollinger et al., 2001
RGS15 = RGS3
RGS16/RGSr	B/R4	202	85%	G_q; Gα_i/o	Gα_t	MIR16; EGFR	Zheng et al., 2000; Derrien, 2001
RGSZ2/RGS17	A/RZ	210	91%		Gα_z
RGS18	B/R4	235		G_i/o; G_q	Gα_i; Gα_q
RGS-GAIP/RGS19	A/RZ	217	90%	G_i	Gα_i3; Gα_z	GIPC(aka SEMCAP, NIP)	De Vries et al., 1998b
RGSZ1/RGS20	A/RZ	241			Gα_z
ret-RGS1	A/RZ	374			Gα_t; Gα_z
PDZ-RGS3		930 (mouse)				Ephrin-B	Lu et al., 2001
p115RhoGEF^1-d	F/RL	912		G_12/13	Gα₁₃	RhoA	Hart et al., 1998
D-AKAP	F/RL	372				r-PKA	Huang et al., 1997
GRK2^1-d	F/RL	689		G_q	Gα_q	GPCR; Gβγ	Ferguson, 2001
RGS-PX1	F/RL	957		G_s	Gα_s	PI₃P/PI₅P	Zheng et al., 2001

↵1-a Amino acids, human or noted.
↵1-b Human to rodent homology where reported.
↵1-c Multiple tested isoforms.
↵1-d Representative subfamily members.