Phosphorylation (Kinase) | PiFunction | Acylation | Lipid Function | |
---|---|---|---|---|
RGS22-150 | PKC | Reduces GAP activity2-a | ||
RGS32-150 | PKC; PKG | 14-3-3 associationb; membrane translocationc | ||
RGS4 | PKG | Membrane translocationc | Palmitate | Membrane bindingi; inhibits GAP activityj |
RGS72-150 | PKC; p38 | 14-3-3 associationb; reduces ubiquitination/degradationd | Palmitate | Membrane localization?k |
RGS102-150 | PKA | Nuclear translocatione | Palmitate | Inhibits GAP in vitro, enhances in vitroj |
RGS16 | EGFR; ? | Enhances GAP activitym; reduces GAP activityf | Palmitate | Required for in vivo Gi/o regulationl |
GAIP/RGS19 | Casein kinase 2g; ERK | Enhances GAP activity to Gi3 h | Palmitate | Membrane attachmentm; microdomain targeting |
↵2-150 Nuclear localization seen with native or recombinant protein.
↵2-a Cunningham et al., 2001;b Benzing et al., 2000;c Pedram et al., 2000;d Benzing et al., 1999;e Burgon et al., 2001;f Chen et al., 2001;g Fischer et al., 2000;h Ogier-Denis et al., 2000;i Tu et al., 2001;j Tu et al., 1999;k Rose et al., 2000;l Druey et al., 1999;m De Vries et al., 1996;n Derrien, 2001.