Table 2

Reported RGS post-translational modifications

	Phosphorylation (Kinase)	P_iFunction	Acylation	Lipid Function
RGS2^2-150	PKC	Reduces GAP activity^2-a
RGS3^2-150	PKC; PKG	14-3-3 association^b; membrane translocation^c
RGS4	PKG	Membrane translocation^c	Palmitate	Membrane bindingⁱ; inhibits GAP activity^j
RGS7^2-150	PKC; p38	14-3-3 association^b; reduces ubiquitination/degradation^d	Palmitate	Membrane localization?^k
RGS10^2-150	PKA	Nuclear translocation^e	Palmitate	Inhibits GAP in vitro, enhances in vitro^j
RGS16	EGFR; ?	Enhances GAP activity^m; reduces GAP activity^f	Palmitate	Required for in vivo G_i/o regulation^l
GAIP/RGS19	Casein kinase 2^g; ERK	Enhances GAP activity to G_i3 ^h	Palmitate	Membrane attachment^m; microdomain targeting

↵2-150 Nuclear localization seen with native or recombinant protein.
↵2-a Cunningham et al., 2001;^b Benzing et al., 2000;^c Pedram et al., 2000;^d Benzing et al., 1999;^e Burgon et al., 2001;^f Chen et al., 2001;^g Fischer et al., 2000;^h Ogier-Denis et al., 2000;ⁱ Tu et al., 2001;^j Tu et al., 1999;^k Rose et al., 2000;^l Druey et al., 1999;^m De Vries et al., 1996;ⁿ Derrien, 2001.