Transport Protein | Typical Substrates | Gender Difference (Species/Tissue) | Sex-Hormone Treatment | Reference | |
---|---|---|---|---|---|
Testosterone | Estradiol | ||||
Oatp mRNA/protein | Bromosulfophthalein, taurocholate, ouabain, cortisol, dexamethasone, ajmalinium | Male > female (rat/kidney) male = female (rat/liver) | Strong increase | Decrease | Lu et al., 1996; Simon et al., 1999 |
rOAT1 protein | PAH, PGE2, urate, salicylate, methotrexate, cAMP, indomethacin, folate | Male > female (rat/kidney) | N.D. | N.D. | Cerrutti et al., 2002 |
rOCT1 mRNA | Choline, dopamine, epinephrine, serotonin, norepinephrine, MPP, NMN, tyramine | None (rat/kidney) | No effect | No effect | Urakami et al., 1999, 2000 |
rOCT2 mRNA/protein | Amantadine, TEA, choline, dopamine | Male > female (rat/kidney) | Increase | Moderate decrease | Urakami et al., 1999, 2000 |
rOCT3 mRNA | Dopamine, guanidine, MPP, TEA | None (rat/kidney) | N.D. | N.D. | Urakami et al., 1999 |
mdr1a mRNA | Hydrophobic (cationic) compounds, anticancer agents, digoxin, immunosuppressants, steroids | Female > male (rat/liver) | N.D. | N.D. | Piquette-Miller et al., 1998 |
mdr1b mRNA | Hydrophobic (cationic) compounds, anticancer agents, digoxin, immunosuppressants, steroids | Male > female (rat/liver) female > male (mouse/kidney) | N.D. | N.D. | Schinkel et al., 1994; Piquette-Miller et al., 1998 |
Mdr2 mRNA | Phospholipids, cholesterol | Female > male (rat/liver) | N.D. | N.D. | Furuya et al., 1994; Salphati and Benet, 1998 |
MDR total protein | Hydrophobic (cationic) compounds, anticancer agents, digoxin, immunosuppressants, steroids | Female > male (rat/liver) Male > female (human/liver) | N.D. | N.D. | Schuetz et al., 1995; Piquette-Miller et al., 1998 |
Ntcp mRNA/protein | Bile acids | Male > female (rat/liver) | Decrease | N.D. | Simon et al., 1996, 1999 |
FATP-1 mRNA | Long chain fatty acids | Female > male (human/skeletal muscle) | N.D. | N.D. | Binnert et al., 2000 |
N.D., not determined; PGE2, prostaglandin E2; MPP, N-methyl-4-phenylpyridinium; NMN, N-methylnicotinamide.