Parameter | Total Radioactivity after Oral Administration | Unchanged Drug after Oral Administration | Total Metabolites after Oral Administration |
---|---|---|---|
Male | |||
Cmax | 43.2 μg/ml | 34.2 μg/ml | 11.3 μg/mlc |
AUC | 540 μg·h/ml | 397 μg eq·h/ml | 143 μg·h/mld |
Urinary excretion | 57.4%a | 2.1%b | 52.2%e |
Female | |||
Cmax | 38.7 μg/ml | 36.7 μg/ml | 2.6 μg/mlc |
AUC | 353 μg·h/ml | 326 μg·h/ml | 27 μg·h/mld |
Urinary excretion | 70.4%a | 39.5%b | 29.9%e |
AUC, area under the curve.
↵ a Oral dose of 20 mg/kg [14C]egualen sodium. All values are means expressed as micrograms of egualen equivalents (adapted from Sato et al., 2000). Values with the same superscript letter are significantly different, p < 0.01