Table 1

Outline of the G-protein-coupled receptors present on the β-cell

Receptor TypeG-ProteinEffector Enzyme
Secretin, GLP-1, GIPGs Adenylyl cyclase
Purinergic P1
 A1 Go/Gi Adenylyl cyclase
Purinergic P2Y Go/Gi Adenylyl cyclase
Muscarinic/cholinergicGq Phospholipase C
Adrenergic
 β2 Gs Adenylyl cyclase
 α2 Gi Adenylyl cyclase