IL-10 Homologs | Cellular Source | Biological Effects | Receptor | |
---|---|---|---|---|
In Vivo | In Vitro | |||
IL-19 | Activated monocytes (LPS or GMCSF) | ? | No effects on cytokine synthesis by PBMC ? | ? |
IL-20 | LPS-stimulated PBMC monocytes (?) | Overexpression in mice causes retarding of growth and development, skin abnormalities, and neonatal lethality | Enhancement of IL-10-induced expression of inflammation-related genes (HaCaT) | IL-20Rα IL-20Rβ |
IL-22 | Activated T cells (Th1 ?), IL-9-stimulated mast cells, mesangium cells | Application in adult mice induces acute phase response and basophilia in proximal renal tubules, autocrine factor for mesangium cells | Induction of acute phase response (hepatoma cell lines), inhibition of IL-4 production from Th2 cells, activates Stat3 in hepatocytes but not macrophages | IL-22Rα IL-10Rβ |
AK155 | T cell lines (CD4+ and CD8+) herpesvirus saimiri-infected T cells, activated monocytes (?) | ? | ? | ? |
MDA-7 | Melanoma cells, skin fibroblasts, activated PBMC (LPS or PHA) | Antitumor effects ? | Irreversible growth arrest of tumor (induction of apoptosis or differentiation) inhibition of angiogenesis induction of Th1 type cytokines in PBMC (?) | ? |
AK, Andrea Knappe; PHA, phytohemagglutinin.