Effect of IL-10 on immune cells (Asadullah et al., 1999b)
| Cell Population | Suppression | Induction | Reference |
|---|---|---|---|
| Langerhans cells | Antigen presentation | Enk et al., 1993 | |
| Dermal dendritic cells | CD86 expression, antigen presentation | Mitra et al., 1995 | |
| Monocytes/macrophages | TNF-α, IL-1, 6, 8, 12 production, expression of MHC class II, CD86, CD54, CD40, antigen presentation | IL-1RA production Soluble TNF receptors | De Waal Malefyt et al., 1991a; Fiorentino et al., 1991b; D'Andrea et al., 1993; Jenkins et al., 1994; Hart et al., 1996 |
| Eosinophils | IL-8, GM-CSF liberation | Takanaski et al., 1994, Nakajima et al., 1996 | |
| Neutrophils | TNF-α, IL-1, IL-8 production | IL-1RA production | Cassatella et al., 1994; Jenkins, 1994 |
| Mast cells | TNF-α production | Growth | Lin and Befus, 1997 |
| Antigen-induced histamine liberation | Thompson-Snipes et al., 1991 | ||
| T cells | IL-2 and IFN-γ production, mitogen-induced proliferation | Matsuda et al., 1994 | |
| NK cells | Cytotoxicity | Carson et al., 1995 | |
| B cells | Growth, IgE synthesis | Uejima et al., 1996, Pistoia, 1997 | |
| Keratinocytes | TNF-α, IL-6 secretion capacity (?) | Bécherel et al., 1995; Seifert et al., 2000, 2002 | |
| Endothelial cells | No effects | E-Selection expression | Vora et al., 1996 |