Reduction of fexofenadine bioavailability by fruit juices in humans (Dresser et al., 2002)
| Control | Grapefruit Juice | Orange Juice | Apple Juice | |
|---|---|---|---|---|
| AUC(0-8h) (ng · h/ml) | 1330 ± 109 | 439 ± 44* | 373 ± 19* | 301 ± 33* |
| Cmax (ng/ml) | 288 ± 23 | 110 ± 14* | 96 ± 7* | 81 ± 13* |
| T1/2 (h) | 2.6 ± 0.2 | 3.1 ± 0.2 | 3.4 ± 0.3 | 3.5 ± 0.4 |
| CLr (ml/min) | 78 ± 8 | 74 ± 7 | 86 ± 8 | 92 ± 9 |
Fexofenadine 120 mg with 1200 ml of water, grapefruit juice, orange juice, or apple juice was administered to 10 healthy volunteers. Data are expressed as mean ± S.E.M. Comparisons are between juice and water treatments.
↵* P < 0.001.