TABLE 1

Distribution of MDMA and its metabolites in the rat (after Lim and Foltz, 1988, 1991a, b). Distribution determined via gas chromatography with an ion trap detector, in samples obtained following in vivo and in vitro metabolism of MDMA in Sprague-Dawley rats. (Note that only liver samples were examined for the presence of 2,4,5-trihydroxymethamphetamine, 2,4,5-trihydroxyamphetamine, and 5,6-dihydroxy-1,2-dimethylindole.)

Compound	Specimen
Compound	Urine	Feces	Blood	Liver	Brain
3,4-Methylenedioxymethamphetamine	+	+	+	+	+
3-Hydroxy-4-methoxymethamphetamine	+			+
4-Hydroxy-3-methoxymethamphetamine	++	+	+	++	+
4-Hydroxy-3-methoxyamphetamine	+	+	+	+	+
3,4-Dihydroxymethamphetamine					+
3,4-Methylenedioxyamphetamine	+	++	++	+	++
(4-Hydroxy-3-methoxyphenyl)acetone	+		+	+
[3,4-(Methylenedioxy)phenyl]acetone	+		+	+	+
(3,4-Dihydroxyphenyl)acetone	+
2-Hydroxy-4,5-(methylenedioxy)methamphetamine			+	+	+
2-Hydroxy-4,5-(methylenedioxy)amphetamine			+	+	+
2,4,5-Trihydroxymethamphetamine				+
2,4,5-Trihydroxyamphetamine				+
5,6-Dihydroxy-1,2-dimethylindole				+