Some important adhesion molecules involved in the interaction between leukocytes, endothelium, and the extracellular matrix
| Adhesion Molecules | Cluster Definition | Major Ligands | Distribution |
|---|---|---|---|
| Selectin family | |||
| L-selectin | CD62L | CD34, Glycam-1, MAdCam-1 | Leukocytes |
| P-selectin | CD62P | Sialyl Lewis X | Endothelial cells, platelets |
| E-selectin | CD62E | Sialyl Lewis X | Endothelial cells |
| Integrin family | |||
| VLA-4; α4/β1 | CD49d/CD29 | VCAM-1, fibronectin | Lymphocytes, monocytes |
| VLA-5; α5/β1 | CD49e/CD29 | Fibronectin | Lymphocytes, monocytes |
| LFA-1 | CD11a/CD18 | ICAM-1, -2, -3 | Leukocytes |
| Mac-1 | CD11b/CD18 | ICAM-1, fibrinogen | Granulocytes, monocytes |
| gp150/95 | CD11c/CD18 | ICAM-1, fibrinogen, C3bi | Granulocytes, monocytes |
| Immunoglobulin superfamily | |||
| ICAM-1 | CD54 | LFA-1, Mac-1, gp150/95 | Endothelial cells, leukocytes |
| ICAM-2 | CD102 | LFA-1, Mac-1, DC-SIGN | Endothelial cells |
| ICAM-3 | CD50 | LFA-1, DC-SIGN | Leukocytes |
| VCAM-1 | CD106 | α4/β1, α4/β7 | Endothelial cells |