Receptor sites on sodium channels
| Receptor Site | Toxin or Drug | Domains |
|---|---|---|
| Neurotoxin receptor site 1 | Tetrodotoxin, saxitoxin, μ-conotoxin | IS5—S6, IIS5—S6, IIIS5—S6, IVS5—S6 |
| Neurotoxin receptor site 2 | Veratridine, batrachotoxin, grayanotoxin | IS6, IVS6 |
| Neurotoxin receptor site 3 | α-Scorpion toxins, sea anemone toxins | IS5—IS6, IVS3—S4, IVS5—S6 |
| Neurotoxin receptor site 4 | β-Scorpion toxins | IIS1—S2, IIS3—S4 |
| Neurotoxin receptor site 5 | Brevetoxins, ciguatoxins | IS6, IVS5 |
| Neurotoxin receptor site 6 | δ-conotoxins | Not established |
| Local anesthetic receptor site | Local anesthetic drugs, antiarrhythmic drugs, antiepileptic drugs | IS6, IIIS6, IVS6 |