The gender difference in the urinary excretion of E2-17βG and the effect of androgen hormone on the urinary excretion of E2-17βG in rats (Gotoh et al., 2002)
| Male | Female | ||||
|---|---|---|---|---|---|
| Control | Orchidectomy | Control | Shama | +Testosterone | |
| Css (fmol/ml) | 67.9 ± 3.1 | 59.2 ± 2.5* | 63.4 ± 4.9 | 64.8 ± 4.7 | 80.1 ± 3.4† |
| CLtot (ml/min/kg) | 54.2 ± 3.8 | 63.1 ± 5.1 | 60.4 ± 4.9 | 58.1 ± 2.8 | 45.6 ± 2.3** |
| CLurine (ml/min/kg) | <8.2 × 10−3 | 1.27 ± 0.36* | 1.11 ± 0.27* | 0.919 ± 0.051* | <9.83 × 10−3* † |
| CLbile (ml/min/kg) | 43.9 ± 2.0 | 49.0 ± 2.8 | 39.3 ± 6.5 | 42.1 ± 2.1 | 45.5 ± 4.1 |
| GFR (ml/min/kg) | 11.8 ± 0.8 | 12.1 ± 0.3 | 12.0 ± 0.8 | 9.90 ± 0.30 | 10.6 ± 0.4 |
Each value represents the mean ± S.E. of four to five independent experiments during constant intravenous infusion of [3H]E2-17βG (227 pmol/h/kg) to male and female SD rats.
↵* Significantly different from control male rats (P < 0.01).
↵** Significantly different from control female rats (P < 0.05).
↵† Significantly different from control female rats (P < 0.01).
↵ a Vehicle only.