Common β2-AR coding SNPs and in vitro drug responses.
| Amino Acid Change | Nucleotide Change | Drug Response Studied | Reference |
|---|---|---|---|
| Arg16Gly | 46A→G | Gly16 increased agonist-promoted down-regulation; others find Gly16 may be resistant to desensitization | Green et al., 1994, 1995; Chong et al., 2000; Moore et al., 2000 |
| Gln27Glu | 79C→G | Glu27 resistant to, or blunted, down-regulation | Green et al., 1994, 1995; Chong et al., 2000; Moore et al., 2000 |
| Val34Met | 100G→A | No functional effect reported | |
| Thr164Ile | 491C→T | Decreased functional coupling to Gs; decreased sequestration | Green et al., 1993, 2001; Turki et al., 1996; Buscher et al., 2002 |